Low methionine diet
High methionine intakes can elevate homocysteine levels and risk of depression. Although methionine is essential to human life, some people benefit by limiting, but not eliminating methionine in their diets. Pharmaceutical companies are fighting to be the first to come out with a drug that decreases methionine levels. the users to add it to the custom location. Fresh tumors taken from patients show that many cancers appear to have a biochemical defect that makes them dependent on methionine, including some tumors of the colon, breast, ovary, prostate, and skin. The completely revised edition of a seminal classic offers fresh insights on the treatment of animals in food production and other industries, the latest findings on the health benefits of a vegan diet, expanded information on phytochemicals, and a thoroughly updated food guide. A Low-Methionine Diet May Help Starve Cancer Cells. Methionine dependency is not just present in cancer cell lines in a Petri dish. Similarly, antifungals can attack the unique cell walls of fungus. Unfortunately, the vast majority of common metastatic cancers, such as breast, prostate, colon, and lung, are lethal. Chemotherapy cures only a few types of metastatic cancer. There are breath-sniffing dogs that can pick out people with lung cancer. But since methionine is sourced mainly from food, a better strategy may be to lower methionine levels by lowering methionine intake, eliminating high methionine foods to control cancer growth as well as improve our lifespan (see Methionine Restriction as a Life-Extension Strategy ). Normal breast cells grow no matter what, with or without methionine, but cancer cells need that added methionine to grow. There are mole-sniffing dogs that can pick out skin cancer. So fighting cancer comes down to trying to find and exploit differences between cancer cells and normal cells.
While human studies are sparse, there is some evidence that cancer cells grow less robustly, and sometimes undergo apoptosis (cell death) when deprived of methionine. Low methionine diets increase metabolic flexibility and overall insulin sensitivity and improve lipid metabolism while decreasing systemic inflammation. Evidence suggests that such diets could enhance longevity and help to prevent or treat certain chronic health conditions. It protects liver cells, and helps to prevent lipid peroxidation, and possibly atherosclerosis and elevated cholesterol. The most common indications for a methionine-restricted diet are. It would kill bacteria, but it might kill us, too. Methionine is an essential amino acid — one of the building blocks of protein that cannot be produced by the human body so must come from our food. For such individuals a methionine-restricted diet may be advised. There is growing interest in methionine restricted diets for those who are unaffected by these genetic metabolic disorders. Pesticides can work by attacking the special exoskeleton of insects. Methionine restriction is commonly recommended to help reduce homocysteine accumulation. MTHFR gene mutations can lead to elevated homocysteine. Methionine is an intermediary in the synthesis of cysteine, carnitine, taurine, and other compounds. HOW NOT TO DIE: New York Times Best Seller. We therefore desperately need novel treatment strategies for metastatic cancer, and dietary methionine restriction may be one such strategy. It is one of two sulfur-containing amino acids (the other is cysteine). But fighting cancer is harder because cancer cells are our own cells. Some individuals need to restrict methionine due to inherited disorders that affect methionine metabolism. Tumors use it to generate gaseous sulfur-containing compounds that, interestingly, can be detected by specially trained diagnostic dogs.
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